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Article

Rpb1 foot mutations demonstrate a major role of Rpb4 in mRNA stability during stress situations in yeast.

Biochimica et biophysica acta - 1 May 2016

Garrido-Godino A I, García-López M C, García-Martínez J, Pelechano V, Medina D A, Pérez-Ortín J E, Navarro F

Abstract excerpt

The RPB1 mutants in the foot region of RNA polymerase II affect the assembly of the complex by altering the correct association of both the Rpb6 and the Rpb4/7 dimer. Assembly defects alter both transcriptional activity as well as the amount of enzyme associated with genes. Here, we show that the global transcriptional analysis of foot mutants reveals the activation of an environmental stress response (ESR),...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27001033
DOI: 10.1016/j.bbagrm.2016.03.008

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