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Article

Mutations in the Saccharomyces cerevisiae RPB1 gene conferring hypersensitivity to 6-azauracil.

Genetics - 1 Apr 2006

Malagon Francisco, Kireeva Maria L, Shafer Brenda K, Lubkowska Lucyna, Kashlev Mikhail, Strathern Jeffrey N

Abstract excerpt

RNA polymerase II (RNAPII) in eukaryotic cells drives transcription of most messenger RNAs. RNAPII core enzyme is composed of 12 polypeptides where Rpb1 is the largest subunit. To further understand the mechanisms of RNAPII transcription, we isolated and characterized novel point mutants of RPB1 that are sensitive to the nucleotide-depleting drug 6-azauracil (6AU). In this work we reisolated the...

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Identifiers

PMID: 16510790
DOI: 10.1534/genetics.105.052415
PMCID: PMC1456368

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Source receipt: pubmed, retrieved 7 Sept 2026.

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