Article
Novel, gross chromosomal alterations involving PTEN cooperate with allelic loss in prostate cancer.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jun 2012
Reid Alison H M, Attard Gerhardt, Brewer Daniel, Miranda Susana, Riisnaes Ruth, Clark Jeremy, Hylands Lucy, Merson Sue, Vergis Roy, Jameson Charles, Høyer Søren, Sørenson Karina Dalsgaard, Borre Michael, Jones Chris, de Bono Johann S, Cooper Colin S
Abstract excerpt
There is increasing evidence that multiple chromosomal rearrangements occur in prostate cancer. PTEN loss is considered to be a key event in prostate carcinogenesis but the mechanisms of loss remain to be fully elucidated. We hypothesised that gross rearrangements may exist that cause disruption of the PTEN gene in the absence of genomic deletion. We therefore designed a novel fluorescence in situ hybridisation...
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