Analytic validation of a clinical-grade PTEN immunohistochemistry assay in prostate cancer by comparison with PTEN FISH.

doi:10.1038/modpathol.2016.88

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Article

Analytic validation of a clinical-grade PTEN immunohistochemistry assay in prostate cancer by comparison with PTEN FISH.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Aug 2016

Lotan Tamara L, Wei Wei, Ludkovski Olga, Morais Carlos L, Guedes Liana B, Jamaspishvili Tamara, Lopez Karen, Hawley Sarah T, Feng Ziding, Fazli Ladan, Hurtado-Coll Antonio, McKenney Jesse K, Simko Jeffrey, Carroll Peter R, Gleave Martin, Lin Daniel W, Nelson Peter S, Thompson Ian M, True Lawrence D, Brooks James D, Lance Raymond, Troyer Dean, Squire Jeremy A

Abstract excerpt

PTEN loss is a promising prognostic and predictive biomarker in prostate cancer. Because it occurs most commonly via PTEN gene deletion, we developed a clinical-grade, automated, and inexpensive immunohistochemical assay to detect PTEN loss. We studied the sensitivity and specificity of PTEN immunohistochemistry relative to four-color fluorescence in situ hybridization (FISH) for detection of PTEN gene deletion...

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PMID: 27174589
DOI: 10.1038/modpathol.2016.88
PMCID: PMC4967011

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PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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