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Article

Polygenic Mendelian Randomization.

Cold Spring Harbor perspectives in medicine - 1 Feb 2021

Dudbridge Frank

Abstract excerpt

Many exposures considered in Mendelian randomization (MR) studies are polygenic in that they are influenced by thousands of genetic variants. By using many single-nucleotide polymorphisms (SNPs) as instrumental variables, more variation in the exposure is explained, increasing the precision of MR. Furthermore, methods can be designed that relax the assumptions of MR, especially concerning direct pleiotropic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32229610
DOI: 10.1101/cshperspect.a039586
PMCID: PMC7849343

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