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Article

Hepatitis C virus replication and Golgi function in brefeldin a-resistant hepatoma-derived cells.

PloS one - 1 Jan 2013

Farhat Rayan, Goueslain Lucie, Wychowski Czeslaw, Belouzard Sandrine, Fénéant Lucie, Jackson Catherine L, Dubuisson Jean, Rouillé Yves

Abstract excerpt

Recent reports indicate that the replication of hepatitis C virus (HCV) depends on the GBF1-Arf1-COP-I pathway. We generated Huh-7-derived cell lines resistant to brefeldin A (BFA), which is an inhibitor of this pathway. The resistant cell lines could be sorted into two phenotypes regarding BFA-induced toxicity, inhibition of albumin secretion, and inhibition of HCV infection. Two cell lines were more than 100...

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Source

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Identifiers

PMID: 24058576
DOI: 10.1371/journal.pone.0074491
PMCID: PMC3776844

Genes

GBF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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