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Article

Brefeldin A-resistant mutants of human epidermoid carcinoma cell line with structural changes of the Golgi apparatus.

The Journal of biological chemistry - 5 Jun 1992

Seguchi T, Goto Y, Ono M, Fujiwara T, Shimada T, Kung H F, Nishioka M, Ikehara Y, Kuwano M

Abstract excerpt

We have isolated brefeldin A (BFA)-resistant cell lines, KB/BF-1 and KB/BF-2, from the human epidermoid carcinoma KB cell line. The BFA-resistant phenotypes have been stably maintained for more than 3 months in the absence of BFA. KB/BF-1 and KB/BF-2 showed 10-30-fold higher resistance to cytotoxicity of BFA but were 2-3-fold more sensitive to monensin and nigericin, than KB cells. KB/BF-1 showed aberrant...

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PMID: 1597488

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