Brefeldin A-resistant mutants of human epidermoid carcinoma cell line with structural changes of the Golgi apparatus.

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Article

Brefeldin A-resistant mutants of human epidermoid carcinoma cell line with structural changes of the Golgi apparatus.

The Journal of biological chemistry - 5 Jun 1992

Seguchi T, Goto Y, Ono M, Fujiwara T, Shimada T, Kung H F, Nishioka M, Ikehara Y, Kuwano M

Abstract excerpt

We have isolated brefeldin A (BFA)-resistant cell lines, KB/BF-1 and KB/BF-2, from the human epidermoid carcinoma KB cell line. The BFA-resistant phenotypes have been stably maintained for more than 3 months in the absence of BFA. KB/BF-1 and KB/BF-2 showed 10-30-fold higher resistance to cytotox...

Topics

Brefeldin A
Carcinoma, Squamous Cell
Cyclopentanes
Drug Resistance
Electrophoresis, Polyacrylamide Gel
Humans
Microscopy, Electron
Microscopy, Fluorescence
Monensin
Mutation
Precipitin Tests
Receptors, LDL
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 1597488

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1597488-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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