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Article

Highly conserved motifs within the large Sec7 ARF guanine nucleotide exchange factor GBF1 target it to the Golgi and are critical for GBF1 activity.

American journal of physiology. Cell physiology - 1 Jun 2018

Pocognoni Cristian A, Viktorova Ekaterina G, Wright John, Meissner Justyna M, Sager Garrett, Lee Eunjoo, Belov George A, Sztul Elizabeth

Abstract excerpt

Cellular life requires the activation of the ADP-ribosylation factors (ARFs) by Golgi brefeldin A-resistant factor 1 (GBF1), a guanine nucleotide exchange factor (GEF) with a highly conserved catalytic Sec7 domain (Sec7d). In addition to the Sec7d, GBF1 contains other conserved domains whose functions remain unclear. Here, we focus on HDS2 (homology downstream of Sec7d 2) domain because the L1246R substitution...

Topics

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Amino Acid Motifs
Golgi Apparatus
Guanine Nucleotide Exchange Factors
Homeostasis
Protein Conformation, alpha-Helical

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Interaction Domains and Motifs

Secretory Pathway

Zebrafish Proteins

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Identifiers

PMID: 29443553
DOI: 10.1152/ajpcell.00221.2017
PMCID: PMC6338321

Genes

GBF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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