Article
Mouse hepatitis coronavirus RNA replication depends on GBF1-mediated ARF1 activation.
PLoS pathogens - 13 Jun 2008
Verheije Monique H, Raaben Matthijs, Mari Muriel, Te Lintelo Eddie G, Reggiori Fulvio, van Kuppeveld Frank J M, Rottier Peter J M, de Haan Cornelis A M
Abstract excerpt
Coronaviruses induce in infected cells the formation of double membrane vesicles, which are the sites of RNA replication. Not much is known about the formation of these vesicles, although recent observations indicate an important role for the endoplasmic reticulum in the formation of the mouse hepatitis coronavirus (MHV) replication complexes (RCs). We now show that MHV replication is sensitive to brefeldin A...
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