Article
Permissiveness of human biliary epithelial cells to infection by hepatitis C virus.
Hepatology (Baltimore, Md.) - 1 May 1999
Loriot M A, Bronowicki J P, Lagorce D, Lakehal F, Persico T, Barba G, Mergey M, Vons C, Franco D, Belghiti J, Giacca M, Housset C, Bréchot C
Abstract excerpt
The cellular tropism of hepatitis C virus (HCV) is an important but much debated issue. Permissivity to HCV of biliary cells has never been demonstrated. In this context, we used gallbladder epithelial cells (GBEC) as a model of the more proximal biliary epithelium. These cells were isolated from HCV-positive and -negative individuals and cultured for up to 40 days. Biliary cells from HCV-negative subjects were...
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