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Article

The poliovirus replication machinery can escape inhibition by an antiviral drug that targets a host cell protein.

Journal of virology - 1 Apr 2004

Crotty Shane, Saleh Maria-Carla, Gitlin Leonid, Beske Oren, Andino Raul

Abstract excerpt

Viral replication depends on specific interactions with host factors. For example, poliovirus RNA replication requires association with intracellular membranes. Brefeldin A (BFA), which induces a major rearrangement of the cellular secretory apparatus, is a potent inhibitor of poliovirus RNA replication. Most aspects governing the relationship between viral replication complex and the host membranes remain poorly...

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Identifiers

PMID: 15016860
DOI: 10.1128/jvi.78.7.3378-3386.2004
PMCID: PMC371039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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