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Article

Gene delivery of a mutant TGFβ3 reduces markers of scar tissue formation after cutaneous wounding.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Dec 2010

Waddington Simon N, Crossley Rachel, Sheard Vicky, Howe Steven J, Buckley Suzanne M K, Coughlan Lynda, Gilham David E, Hawkins Robert E, McKay Tristan R

Abstract excerpt

The transforming growth factor-β (TGFβ) family plays a critical regulatory role in repair and coordination of remodeling after cutaneous wounding. TGFβ1-mediated chemotaxis promotes the recruitment of fibroblasts to the wound site and their resultant myofibroblastic transdifferentiation that is responsible for elastic fiber deposition and wound closure. TGFβ3 has been implicated in an antagonistic role regulating...

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Identifiers

PMID: 20736928
DOI: 10.1038/mt.2010.174
PMCID: PMC2997585

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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