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Article

Gene delivery of a mutant TGFβ3 reduces markers of scar tissue formation after cutaneous wounding.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Dec 2010

Waddington Simon N, Crossley Rachel, Sheard Vicky, Howe Steven J, Buckley Suzanne M K, Coughlan Lynda, Gilham David E, Hawkins Robert E, McKay Tristan R

Abstract excerpt

The transforming growth factor-β (TGFβ) family plays a critical regulatory role in repair and coordination of remodeling after cutaneous wounding. TGFβ1-mediated chemotaxis promotes the recruitment of fibroblasts to the wound site and their resultant myofibroblastic transdifferentiation that is r...

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Identifiers

PMID: 20736928
DOI: 10.1038/mt.2010.174
PMCID: PMC2997585

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20736928-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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