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Article

TGFβ2 and TGFβ3 isoforms drive fibrotic disease pathogenesis

4 Aug 2021

Abstract excerpt

expression is increased in human lung and liver fibrotic tissues compared to healthy control tissues. Thus, TGFβ2 and TGFβ3 may play a pathological role in fibrosis. Inducible conditional knockout mice and anti-TGFβ isoform-selective antibodies demonstrated that TGFβ2 and TGFβ3 are independently involved in mouse fibrosis models in vivo, and selective TGFβ2 and TGFβ3 inhibition does not lead to the increased...

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PMID: 34349032
DOI: 10.1126/scitranslmed.abe0407

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