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Article

Variants in two adjacent genes, EGLN2 and CYP2A6, influence smoking behavior related to disease risk via different mechanisms.

Human molecular genetics - 15 Jan 2014

Bloom A Joseph, Baker Timothy B, Chen Li-Shiun, Breslau Naomi, Hatsukami Dorothy, Bierut Laura J, Goate Alison

Abstract excerpt

Genome-wide significant associations with cigarettes per day (CPD) and risk for lung cancer and chronic obstructive pulmonary disease (COPD) were previously reported in a region of 19q13, including CYP2A6 (nicotine metabolism enzyme) and EGLN2 (hypoxia response). The associated single nucleotide polymorphisms (SNPs) were assumed to be proxies for functional variation in CYP2A6. Here, we demonstrate that when...

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Share to Aryl Hydrocarbon Hydroxylases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 19

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Source

Open in PubMed Open full text

Identifiers

PMID: 24045616
DOI: 10.1093/hmg/ddt432
PMCID: PMC3869360

Genes

EGLN2
CPD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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