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Article

A Case-Control Study of the Associations between EGLN1 Gene Polymorphisms and COPD.

Frontiers in bioscience (Landmark edition) - 17 Jan 2024

Li Xin, Zhang Peng, Yu Jing, Zhang Chunyan, Shi Yanli, Wei Xueyan, Li Honge, Zhang Xuhui, Lin Ao, Yang Zhen, Wang Yunchao, Wang Xinhua

Abstract excerpt

BACKGROUND: Environmental and genetic factors are jointly involved in the development of chronic obstructive pulmonary disease (COPD). The EGLN1 gene is a major factor in upstream regulation of the hypoxia-inducible pathway. EGLN1 negatively regulates the hypoxia-inducible factors HIF-lα and HIF-2α by regulating the concentration of oxygen, mainly in a hypoxic environment. Hypoxia is a common physiologic...

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Source

Identifiers

PMID: 38287821
DOI: 10.31083/j.fbl2901018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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