Article
COPD GWAS variant at 19q13.2 in relation with DNA methylation and gene expression.
Human molecular genetics - 15 Jan 2018
Nedeljkovic Ivana, Lahousse Lies, Carnero-Montoro Elena, Faiz Alen, Vonk Judith M, de Jong Kim, van der Plaat Diana A, van Diemen Cleo C, van den Berge Maarten, Obeidat Ma'en, Bossé Yohan, Nickle David C, Consortium B I O S, Uitterlinden Andre G, van Meurs Joyce B J, Stricker Bruno H C, Brusselle Guy G, Postma Dirkje S, Boezen H Marike, van Duijn Cornelia M, Amin Najaf
Abstract excerpt
Chronic obstructive pulmonary disease (COPD) is among the major health burdens in adults. While cigarette smoking is the leading risk factor, a growing number of genetic variations have been discovered to influence disease susceptibility. Epigenetic modifications may mediate the response of the genome to smoking and regulate gene expression. Chromosome 19q13.2 region is associated with both smoking and COPD, yet...
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