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Article

Beyond cigarettes per day. A genome-wide association study of the biomarker carbon monoxide.

Annals of the American Thoracic Society - 1 Sept 2014

Bloom A Joseph, Hartz Sarah M, Baker Timothy B, Chen Li-Shiun, Piper Megan E, Fox Louis, Martinez Maribel, Hatsukami Dorothy, Johnson Eric O, Laurie Cathy C, Saccone Nancy L, Goate Alison, Bierut Laura J

Abstract excerpt

RATIONALE: The CHRNA5-CHRNA3-CHRNB4 locus is associated with self-reported smoking behavior and also harbors the strongest genetic associations with chronic obstructive pulmonary disease (COPD) and lung cancer. Because the associations with lung disease remain after adjustment for self-reported smoking behaviors, it has been asserted that CHRNA5-CHRNA3-CHRNB4 variants increase COPD and lung cancer susceptibility...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Cytochrome P-450 CYP2A6

Share to Pulmonary Disease, Chronic Obstructive

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Source

Open in PubMed Open full text

Identifiers

PMID: 25072098
DOI: 10.1513/AnnalsATS.201401-010OC
PMCID: PMC4214060

Genes

CHRNA5
CHRNA3
CHRNB4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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