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Article

Deep Sequencing of Three Loci Implicated in Large-Scale Genome-Wide Association Study Smoking Meta-Analyses.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco - 1 May 2016

Clark Shaunna L, McClay Joseph L, Adkins Daniel E, Aberg Karolina A, Kumar Gaurav, Nerella Sri, Xie Linying, Collins Ann L, Crowley James J, Quakenbush Corey R, Hillard Christopher E, Gao Guimin, Shabalin Andrey A, Peterson Roseann E, Copeland William E, Silberg Judy L, Maes Hermine, Sullivan Patrick F, Costello Elizabeth J, van den Oord Edwin J

Abstract excerpt

INTRODUCTION: Genome-wide association study meta-analyses have robustly implicated three loci that affect susceptibility for smoking: CHRNA5\CHRNA3\CHRNB4, CHRNB3\CHRNA6 and EGLN2\CYP2A6. Functional follow-up studies of these loci are needed to provide insight into biological mechanisms. However, these efforts have been hampered by a lack of knowledge about the specific causal variant(s) involved. In this study,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26283763
DOI: 10.1093/ntr/ntv166
PMCID: PMC5942610

Genes

CHRNA6
CHRNB3
CHRNB4
EGLN2
CHRNA3
CHRNA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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