Article
ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response.
Cell reports - 25 Apr 2013
Heijmans Jarom, van Lidth de Jeude Jooske F, Koo Bon-Kyoung, Rosekrans Sanne L, Wielenga Mattheus C B, van de Wetering Marc, Ferrante Marc, Lee Amy S, Onderwater Jos J M, Paton James C, Paton Adrienne W, Mommaas A Mieke, Kodach Liudmila L, Hardwick James C, Hommes Daniël W, Clevers Hans, Muncan Vanesa, van den Brink Gijs R
Abstract excerpt
Stem cells generate rapidly dividing transit-amplifying cells that have lost the capacity for self-renewal but cycle for a number of times until they exit the cell cycle and undergo terminal differentiation. We know very little of the type of signals that trigger the earliest steps of stem cell differentiation and mediate a stem cell to transit-amplifying cell transition. We show that in normal intestinal...
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