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Article

XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease.

Cell - 5 Sept 2008

Kaser Arthur, Lee Ann-Hwee, Franke Andre, Glickman Jonathan N, Zeissig Sebastian, Tilg Herbert, Nieuwenhuis Edward E S, Higgins Darren E, Schreiber Stefan, Glimcher Laurie H, Blumberg Richard S

Abstract excerpt

Inflammatory bowel disease (IBD) has been attributed to aberrant mucosal immunity to the intestinal microbiota. The transcription factor XBP1, a key component of the endoplasmic reticulum (ER) stress response, is required for development and maintenance of secretory cells and linked to JNK activation. We hypothesized that a stressful environmental milieu in a rapidly proliferating tissue might instigate a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18775308
DOI: 10.1016/j.cell.2008.07.021
PMCID: PMC2586148

Genes

XBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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