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Article

Endoplasmic reticulum stress in the intestinal epithelium and inflammatory bowel disease.

Seminars in immunology - 1 Jun 2009

Kaser Arthur, Blumberg Richard S

Abstract excerpt

The unfolded protein response as a consequence of endoplasmic reticulum (ER) stress has recently been implicated as a novel mechanism that may lead to inflammatory bowel disease (IBD). Impairment of proper ER stress resolution in highly secretory Paneth and, to a lesser extent, goblet cells within the epithelium can primarily lead to intestinal inflammation. An inability to manage ER stress may not only be a...

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Source

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Identifiers

PMID: 19237300
DOI: 10.1016/j.smim.2009.01.001
PMCID: PMC4736746

Genes

XBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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