Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The minimal polymorphism of class II E alpha chains is not due to the functional neutrality of mutations.

Immunogenetics - 1 Jan 1994

Chu Z T, Carswell-Crumpton C, Cole B C, Jones P P

Abstract excerpt

Given the extensive allelic amino acid sequence polymorphism present in the first domain of A alpha, A beta, and E beta chains and its profound effects on class II function, the minimal polymorphism in the mouse E alpha chain (and in its human homologue DR alpha) is paradox. Two possible explanations for the lack of polymorphism in E alpha are: (1) the E alpha chain plays such a uniquely critical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Mice
Share to Models, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutation

Share to Polymorphism, Genetic

Share to Sequence Homology, Amino Acid

Share to Transfection

Source

Identifiers

PMID: 8206532
DOI: 10.1007/BF00163959

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The minimal polymorphism of class II E alpha chains is not due to the functional neutrality of mutations.PMID 8206532Read ↗

Polymorphism at the HLA-E locus predates most HLA-A and -B polymorphism.Semantic proximity Read ↗

Structural diversity of the classical H-2 genes: K, D, and L.Semantic proximity Read ↗

HLA-E allelic variants. Correlating differential expression, peptide affinities, crystal structures, and thermal stabilities.Semantic proximity Read ↗

Superantigens interact with MHC class II molecules outside of the antigen groove.Semantic proximity Read ↗

Inactivation of E alpha and E beta expression in inbred and wild mice by multiple distinct mutations, some of which predate speciation within Mus species.Semantic proximity Read ↗

Functional and phenotypic evidence for presentation of E alpha 52-68 structurally related self-peptide(s) in I-E alpha-deficient mice.Semantic proximity Read ↗

The Immunodominant CD8 T Cell Response to the Human Cytomegalovirus Tegument Phosphoprotein pp65495–503 Epitope Critically Depends on CD4 T Cell Help in Vaccinated HLA-A*0201 Transgenic MiceSemantic proximity Read ↗

Single amino acid substitutions determine mouse CD8 allotypes: epitope mapping of mouse CD8.Semantic proximity Read ↗

E variants found in Japanese and c antigenicity alteration without substitution in the second extracellular loop.Semantic proximity Read ↗

A conservative mutation in a class I MHC molecule outside the peptide binding groove stimulates responses to self peptides.Semantic proximity Read ↗

Peptide-induced HLA-E expression in human PBMCs is dependent on peptide sequence and the HLA-E genotype.Semantic proximity Read ↗

Allelic differences in TCR gamma-chains alter gamma delta T cell antigen reactivity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.