The minimal polymorphism of class II E alpha chains is not due to the functional neutrality of mutations.

doi:10.1007/BF00163959

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Article

The minimal polymorphism of class II E alpha chains is not due to the functional neutrality of mutations.

Immunogenetics - 1 Jan 1994

Chu Z T, Carswell-Crumpton C, Cole B C, Jones P P

Abstract excerpt

Given the extensive allelic amino acid sequence polymorphism present in the first domain of A alpha, A beta, and E beta chains and its profound effects on class II function, the minimal polymorphism in the mouse E alpha chain (and in its human homologue DR alpha) is paradox. Two possible explanat...

Topics

Amino Acid Sequence
Animals
Antigen Presentation
HLA-DR Antigens
Histocompatibility Antigens Class II
Humans
Hybridomas
Mice
Models, Molecular
Molecular Sequence Data
Mutation
Polymorphism, Genetic
Sequence Homology, Amino Acid
Superantigens
T-Lymphocytes
Transfection

Source

Open in PubMed

Identifiers

PMID: 8206532
DOI: 10.1007/BF00163959

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8206532-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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