Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Proteolytic processing in development and leukemogenesis.

Cell - 31 Oct 2003

Gilliland D Gary

Abstract excerpt

There are now numerous examples in the hematopoietic system of genes that are critical for normal hematopoietic development, but when mutated, rearranged, or overexpressed, contribute to leukemogenesis. Two papers in this issue of Cell provide a fascinating twist on this paradigm, and suggest that proteolytic processing of certain of these genes plays an important role both in development and in leukemogenesis....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Proto-Oncogenes
Share to Endopeptidases
Share to Histone-Lysine N-Methyltransferase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Leukemia, Promyelocytic, Acute

Share to Leukocyte Elastase

Share to Myeloid-Lymphoid Leukemia Protein

Share to Oncogene Proteins, Fusion

Share to Threonine

Source

Identifiers

PMID: 14636551
DOI: 10.1016/s0092-8674(03)00854-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Proteolytic processing in development and leukemogenesis.PMID 14636551Read ↗

Metalloproteinases: a Functional Pathway for Myeloid CellsSemantic proximity Read ↗

Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cellsSemantic proximity Read ↗

MLL becomes functional through intra-molecular interaction not by proteolytic processing.Semantic proximity Read ↗

Metacaspases versus caspases in development and cell fate regulationSemantic proximity Read ↗

Human and mouse proteases: a comparative genomic approachSemantic proximity Read ↗

HoxA10 Activates Transcription of the Gene Encoding Mitogen-activated Protein Kinase Phosphatase 2 (Mkp2) in Myeloid CellsSemantic proximity Read ↗

Phenotypic characterization of KU812, a cell line identified as an immature human basophilic leukocyte.Semantic proximity Read ↗

Redundancy and specificity of the metalloprotease system mediating oncogenic NOTCH1 activation in T-ALL.Semantic proximity Read ↗

The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain.Semantic proximity Read ↗

Autoproteolysis in hedgehog protein biogenesis.Semantic proximity Read ↗

A lineage-specific protein kinase crucial for myeloid maturation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.