Article

The Menin Tumor Suppressor Protein Is an Essential Oncogenic Cofactor for MLL-Associated Leukemogenesis.

2005-11-16

Abstract excerpt

Abstract The Mixed Lineage Leukemia (MLL) protein is a histone methyltransferase that is mutated in clinically and biologically distinctive subsets of acute leukemia. MLL normally associates with a cohort of highly conserved cofactors to form a macromolecular complex that includes menin, a product of the MEN1 tumor suppressor gene, which is mutated in heritable and sporadic endocrine tumors. We demonstrate here th...

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Literature Corpus work: 2d14bfbb-56fc-56d8-80cb-a93e05316a56
DOI: 10.1182/blood.v106.11.665.665

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