Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors.

Cell stem cell - 13 Sept 2007

Jude Craig D, Climer Leslie, Xu Diyong, Artinger Erika, Fisher Jill K, Ernst Patricia

Abstract excerpt

The Mixed Lineage Leukemia (MLL) gene is essential for embryonic hematopoietic stem cell (HSC) development, but its role during adult hematopoiesis is unknown. Using an inducible knockout model, we demonstrate that Mll is essential for the maintenance of adult HSCs and progenitors, with fatal bone marrow failure occurring within 3 weeks of Mll deletion. Mll-deficient cells are selectively lost from mixed bone...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow
Share to Cell Count
Share to Chimera

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Erythroid Precursor Cells

Share to Hematopoietic Stem Cells

Share to Myeloid Cells

Share to Myeloid-Lymphoid Leukemia Protein

Share to Myeloid Progenitor Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 18371366
DOI: 10.1016/j.stem.2007.05.019
PMCID: PMC2234224

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors.PMID 18371366Read ↗

Definitive hematopoiesis requires the mixed-lineage leukemia gene.Semantic proximity Read ↗

Impaired function of primitive hematopoietic cells in mice lacking the Mixed-Lineage-Leukemia homolog MLL5.Semantic proximity Read ↗

Hematopoietic Stem Cells Are Intrinsically Protected against MLL-ENL-Mediated TransformationSemantic proximity Read ↗

Modeling the Initiation and Progression of Human Acute Leukemia in MiceSemantic proximity Read ↗

Dysregulation of haematopoietic stem cell regulatory programs in acute myeloid leukaemia.Semantic proximity Read ↗

Defining leukemia stem cells in MLL-translocated leukemias: implications for novel therapeutic strategies.Semantic proximity Read ↗

An MLL-dependent network sustains hematopoiesisSemantic proximity Read ↗

Defects in Yolk Sac Hematopoiesis in Mll-Null EmbryosSemantic proximity Read ↗

Leukemogenesis via aberrant self-renewal by the MLL/AEP-mediated transcriptional activation system.Semantic proximity Read ↗

Musashi2 sustains the mixed-lineage leukemia–driven stem cell regulatory programSemantic proximity Read ↗

Leukemia and hematopoietic stem cells: balancing proliferation and quiescence.Semantic proximity Read ↗

Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.