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Article

Taspase1 cleaves MLL1 to activate cyclin E for HER2/neu breast tumorigenesis.

Cell research - 1 Nov 2014

Dong Yiyu, Van Tine Brian A, Oyama Toshinao, Wang Patricia I, Cheng Emily H, Hsieh James J

Abstract excerpt

Taspase1, a highly conserved threonine protease, cleaves nuclear transcriptional regulators mixed-lineage leukemia (MLL, MLL1), MLL2, TFIIA, and ALF to orchestrate a wide variety of biological processes. In vitro studies thus far demonstrated that Taspase1 plays important roles in the proliferati...

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Identifiers

PMID: 25267403
DOI: 10.1038/cr.2014.129
PMCID: PMC4220155

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25267403-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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