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Article

Epigenetic regulator MLL2 shows altered expression in cancer cell lines and tumors from human breast and colon

1 Jan 2010

Abstract excerpt

BACKGROUND: MLL2, an epigenetic regulator in mammalian cells, mediates histone 3 lysine 4 tri-methylation (H3K4me3) through the formation of a multiprotein complex. MLL2 shares a high degree of structural similarity with MLL, which is frequently disrupted in leukemias via chromosomal translocations. However, this structural similarity is not accompanied by functional equivalence. In light of this difference, and...

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PMID: 20433758
DOI: 10.1186/1475-2867-10-13

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