Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models.

Nature communications - 13 Feb 2018

Sokhi Upneet K, Liber Mark P, Frye Laura, Park Sungho, Kang Kyuho, Pannellini Tania, Zhao Baohong, Norinsky Rada, Ivashkiv Lionel B, Gong Shiaoching

Abstract excerpt

Enhancers regulate gene expression and have been linked with disease pathogenesis. Little is known about enhancers that regulate human disease-associated genes in primary cells relevant for pathogenesis. Here we use BAC transgenics and genome editing to dissect, in vivo and in primary immune cells, enhancers that regulate human TNFAIP3, which encodes A20 and is linked with autoimmune diseases. A20 expression is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arthritis, Rheumatoid
Share to Autoimmune Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Autoimmunity

Share to Enhancer Elements, Genetic

Share to HEK293 Cells

Share to Mice, Knockout

Share to Mice, Transgenic

Share to Tumor Necrosis Factor alpha-Induced Protein 3

Source

Open in PubMed Open full text

Identifiers

PMID: 29440643
DOI: 10.1038/s41467-018-03081-7
PMCID: PMC5811492

Genes

TNFAIP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models.PMID 29440643Read ↗

Genetic relationships between A20/TNFAIP3, chronic inflammation and autoimmune disease.Semantic proximity Read ↗

TALEN-mediated enhancer knockout influences TNFAIP3 gene expression and mimics a molecular phenotype associated with systemic lupus erythematosus.Semantic proximity Read ↗

An enhancer element harboring variants associated with systemic lupus erythematosus engages the TNFAIP3 promoter to influence A20 expression.Semantic proximity Read ↗

Single nucleotide polymorphisms at the TNFAIP3/A20 locus and susceptibility/resistance to inflammatory and autoimmune diseases.Semantic proximity Read ↗

Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease.Semantic proximity Read ↗

Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus.Semantic proximity Read ↗

Preserving immune homeostasis with A20.Semantic proximity Read ↗

The research potential of A20 in psoriatic arthritis.Semantic proximity Read ↗

Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis.Semantic proximity Read ↗

Integration of genetic and epigenetic data pinpoints autoimmune specific remodelling of enhancer landscape in CD4+ T cellsSemantic proximity Read ↗

Discovery of an autoimmunity-associated <i>IL2RA</i> enhancer by unbiased targeting of transcriptional activationSemantic proximity Read ↗

Mechanistic dissection of dominant AIRE mutations in mouse models reveals AIRE autoregulation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.