Article
Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus.
Nature genetics - 1 Sept 2008
Musone Stacy L, Taylor Kimberly E, Lu Timothy T, Nititham Joanne, Ferreira Ricardo C, Ortmann Ward, Shifrin Nataliya, Petri Michelle A, Kamboh M Ilyas, Manzi Susan, Seldin Michael F, Gregersen Peter K, Behrens Timothy W, Ma Averil, Kwok Pui-Yan, Criswell Lindsey A
Abstract excerpt
The TNFAIP3 (tumor necrosis factor alpha-induced protein 3) gene encodes a ubiquitin editing enzyme, A20, that restricts NF-kappaB-dependent signaling and prevents inflammation. We show that three independent SNPs in the TNFAIP3 region (rs13192841, rs2230926 and rs6922466) are associated with systemic lupus erythematosus (SLE) among individuals of European ancestry. These findings provide critical links between...
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