Article
Meta-analysis and imputation identifies a 109 kb risk haplotype spanning TNFAIP3 associated with lupus nephritis and hematologic manifestations.
Genes and immunity - 1 Jul 2009
Bates J S, Lessard C J, Leon J M, Nguyen T, Battiest L J, Rodgers J, Kaufman K M, James J A, Gilkeson G S, Kelly J A, Humphrey M B, Harley J B, Gray-McGuire C, Moser K L, Gaffney P M
Abstract excerpt
TNFAIP3 encodes the ubiquitin-modifying enzyme, A20, a key regulator of inflammatory signaling pathways. We previously reported association between TNFAIP3 variants and systemic lupus erythematosus (SLE). To further localize the risk variant(s), we performed a meta-analysis using genetic data available from two Caucasian case-control datasets (1453 total cases, 3381 total control subjects) and 713 SLE trio...
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