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Article

Activation of H-ras is prevalent in 1,3-butadiene-induced and spontaneously occurring murine Harderian gland tumors.

Carcinogenesis - 1 Nov 1994

Goodrow T L, Nichols W W, Storer R D, Anderson M W, Maronpot R R

Abstract excerpt

Treatment of B6C3F1 mice with concentrations of 62.5-625 p.p.m. 1,3-butadiene by inhalation for up to 2 years causes a significantly increased incidence of Harderian gland (HG) neoplasms over untreated controls (Melnick,R., Huff,J., Chou,B.J. and Miller,R.A. Cancer Res., 50, 6592-6599, 1990). Since a specific K-ras mutation (codon 13 GGC-->CGC) had previously been described in lung and liver tumors from...

Topics

Animals
Base Sequence
Butadienes
Gene Expression Regulation
Genes, ras
Harderian Gland
Mice
Molecular Sequence Data
Mutation
Neoplasms, Experimental
Rodent Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7955123
DOI: 10.1093/carcin/15.11.2665

Genes

CGA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7955123-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Activation of H-ras is prevalent in 1,3-butadiene-induced and spontaneously occurring murine Harderian gland tumors.PMID 7955123Read ↗

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