Article
Polymorphisms in miRNA-binding sites of nucleotide excision repair genes and colorectal cancer risk.
Carcinogenesis - 1 Jul 2012
Naccarati Alessio, Pardini Barbara, Stefano Landi, Landi Debora, Slyskova Jana, Novotny Jan, Levy Miroslav, Polakova Veronika, Lipska Ludmila, Vodicka Pavel
Abstract excerpt
Reduced DNA repair capacity and DNA damage accumulation may lead to cancer development. Regulation of and coordination between genes involved in DNA repair pathways is fundamental for maintaining genome stability, and post-transcriptional gene regulation by microRNAs (miRNAs) may therefore be of particular relevance. In this context, the presence of single nucleotide polymorphisms (SNPs) within the 3'untranslated...
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