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Article

Double-strand break repair and colorectal cancer: gene variants within 3' UTRs and microRNAs binding as modulators of cancer risk and clinical outcome.

Oncotarget - 26 Apr 2016

Naccarati Alessio, Rosa Fabio, Vymetalkova Veronika, Barone Elisa, Jiraskova Katerina, Di Gaetano Cornelia, Novotny Jan, Levy Miroslav, Vodickova Ludmila, Gemignani Federica, Buchler Tomas, Landi Stefano, Vodicka Pavel, Pardini Barbara

Abstract excerpt

Genetic variations in 3' untranslated regions of target genes may affect microRNA binding, resulting in differential protein expression. microRNAs regulate DNA repair, and single-nucleotide polymorphisms in miRNA binding sites (miRSNPs) may account for interindividual differences in the DNA repair capacity. Our hypothesis is that miRSNPs in relevant DNA repair genes may ultimately affect cancer susceptibility and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26735576
DOI: 10.18632/oncotarget.6804
PMCID: PMC5029617

Genes

RAD52

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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