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Article

An EM algorithm based on an internal list for estimating haplotype distributions of rare variants from pooled genotype data.

BMC genetics - 13 Sept 2013

Kuk Anthony Y C, Li Xiang, Xu Jinfeng

Abstract excerpt

BACKGROUND: Pooling is a cost effective way to collect data for genetic association studies, particularly for rare genetic variants. It is of interest to estimate the haplotype frequencies, which contain more information than single locus statistics. By viewing the pooled genotype data as incomplete data, the expectation-maximization (EM) algorithm is the natural algorithm to use, but it is computationally...

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Identifiers

PMID: 24034507
DOI: 10.1186/1471-2156-14-82
PMCID: PMC3847674

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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