Grouping preprocess to accurately extend application of EM algorithm to haplotype inference.

Abstract excerpt

Haplotype inference is an indispensable technique in medical science, especially in genome-wide association studies. Although the conventional method of inference using the expectation-maximization (EM) algorithm by Excoffier and Slatkin is one standard approach, as its calculation cost is an exponential function of the maximum number of heterozygous loci, it has not been widely applied. We propose a method of...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Algorithms
• Share to Genetics, Medical
• Share to Haplotypes