Article
Maximum-parsimony haplotype frequencies inference based on a joint constrained sparse representation of pooled DNA.
BMC bioinformatics - 8 Sept 2013
Jajamovich Guido H, Iliadis Alexandros, Anastassiou Dimitris, Wang Xiaodong
Abstract excerpt
BACKGROUND: DNA pooling constitutes a cost effective alternative in genome wide association studies. In DNA pooling, equimolar amounts of DNA from different individuals are mixed into one sample and the frequency of each allele in each position is observed in a single genotype experiment. The identification of haplotype frequencies from pooled data in addition to single locus analysis is of separate interest...
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