Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A fast collapsed data method for estimating haplotype frequencies from pooled genotype data with applications to the study of rare variants.

Statistics in medicine - 15 Apr 2013

Kuk Anthony Y C, Li Xiang, Xu Jinfeng

Abstract excerpt

Haplotype information could lead to more powerful tests of genetic association than single-locus analyses but it is not easy to estimate haplotype frequencies from genotype data due to phase ambiguity. The challenge is compounded when individuals are pooled together to save costs or to increase sample size, which is crucial in the study of rare variants. Existing expectation-maximization type algorithms are slow...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Data Interpretation, Statistical
Share to Gene Frequency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Genotyping Techniques

Share to Haplotypes

Share to Likelihood Functions

Share to Models, Statistical

Share to Obesity

Source

Identifiers

PMID: 22855289
DOI: 10.1002/sim.5540

Genes

FAAH
MGLL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A fast collapsed data method for estimating haplotype frequencies from pooled genotype data with applications to the study of rare variants.PMID 22855289Read ↗

An EM algorithm based on an internal list for estimating haplotype distributions of rare variants from pooled genotype data.Semantic proximity Read ↗

A covering method for detecting genetic associations between rare variants and common phenotypes.Semantic proximity Read ↗

Estimating haplotype-disease associations with pooled genotype data.Semantic proximity Read ↗

Maximum-parsimony haplotype frequencies inference based on a joint constrained sparse representation of pooled DNA.Semantic proximity Read ↗

On rare-variant analysis in population-based designs: decomposing the likelihood to two informative components.Semantic proximity Read ↗

Estimating haplotype relative risks in complex disease from unphased SNPs data in families using a likelihood adjusted for ascertainment.Semantic proximity Read ↗

Detecting rare haplotype-environment interaction with logistic Bayesian LASSO.Semantic proximity Read ↗

Estimating population haplotype frequencies from pooled SNP data using incomplete database information.Semantic proximity Read ↗

Haplotype phasing by multi-assembly of shared haplotypes: phase-dependent interactions between rare variants.Semantic proximity Read ↗

A novel tool for individual haplotype inference using mixed data.Semantic proximity Read ↗

PoooL: an efficient method for estimating haplotype frequencies from large DNA pools.Semantic proximity Read ↗

Statistical analysis of rare sequence variants: an overview of collapsing methods.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.