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Article

A unified approach for allele frequency estimation, SNP detection and association studies based on pooled sequencing data using EM algorithms.

BMC genomics - 1 Jan 2013

Chen Quan, Sun Fengzhu

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) have identified many common polymorphisms associated with complex traits. However, these associated common variants explain only a small fraction of the phenotypic variances, leaving a substantial portion of genetic heritability unexplained. As a result, searches for "missing" heritability are drawing increasing attention, particularly for rare variant studies...

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PMID: 23369070
DOI: 10.1186/1471-2164-14-S1-S1
PMCID: PMC3549804

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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