Polyclonal hyper-IgE mouse model reveals mechanistic insights into antibody class switch recombination.

doi:10.1073/pnas.1221661110

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Polyclonal hyper-IgE mouse model reveals mechanistic insights into antibody class switch recombination.

Proceedings of the National Academy of Sciences of the United States of America - 24 Sept 2013

Misaghi Shahram, Senger Kate, Sai Tao, Qu Yan, Sun Yonglian, Hamidzadeh Kajal, Nguyen Allen, Jin Zhaoyu, Zhou Meijuan, Yan Donghong, Lin Wei Yu, Lin Zhonghua, Lorenzo Maria N, Sebrell Andrew, Ding Jiabing, Xu Min, Caplazi Patrick, Austin Cary D, Balazs Mercedesz, Roose-Girma Merone, DeForge Laura, Warming Søren, Lee Wyne P, Dixit Vishva M, Zarrin Ali A

Abstract excerpt

Preceding antibody constant regions are switch (S) regions varying in length and repeat density that are targets of activation-induced cytidine deaminase. We asked how participating S regions influence each other to orchestrate rearrangements at the IgH locus by engineering mice in which the weakest S region, Sε, is replaced with prominent recombination hotspot Sμ. These mice produce copious polyclonal IgE upon...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Knock-In Techniques

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Targeting

Share to Germ Cells

Share to Hybridomas

Share to Immunoglobulin Class Switching

Share to Immunoglobulin E

Share to Immunoglobulin mu-Chains

Share to Models, Animal

Source

Open in PubMed Open full text

Identifiers

PMID: 24019479
DOI: 10.1073/pnas.1221661110
PMCID: PMC3785764

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polyclonal hyper-IgE mouse model reveals mechanistic insights into antibody class switch recombination.PMID 24019479Read ↗

Comparison of identical and functional Igh alleles reveals a nonessential role for Eμ in somatic hypermutation and class-switch recombination.Semantic proximity Read ↗

Stochasticity enables BCR-independent germinal center initiation and antibody affinity maturationSemantic proximity Read ↗

Sequence-Intrinsic Mechanisms that Target AID Mutational Outcomes on Antibody Genes.Semantic proximity Read ↗

B-cell receptor physical properties affect relative IgG1 and IgE responses in mouse egg allergySemantic proximity Read ↗

Complex subsets but redundant clonality after B cells egress from spontaneous germinal centersSemantic proximity Read ↗

Targeting and regulation of immunoglobulin gene somatic hypermutation and isotype switch recombination.Semantic proximity Read ↗

Homologous elements hs3a and hs3b in the 3' regulatory region of the murine immunoglobulin heavy chain (Igh) locus are both dispensable for class-switch recombination.Semantic proximity Read ↗

Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination.Semantic proximity Read ↗

Insufficiency of Genomic Structure in Immunoglobulin Locus for Inducing High-Frequency Gene Conversion in Variable RegionsSemantic proximity Read ↗

Age, microbiota, and T cells shape diverse individual IgA repertoires in the intestine.Semantic proximity Read ↗

Generation of heavy-chain-only antibodies in miceSemantic proximity Read ↗

Antibody diversification: mutational mechanisms and oncogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.