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Article

Generation of heavy-chain-only antibodies in mice

2 Oct 2006

Abstract excerpt

We have generated transgenic mice containing hybrid llama/human antibody loci that contain two llama variable regions and the human D, J, and Cmu and/or Cgamma constant regions. Such loci rearrange productively and rescue B cell development efficiently without LC rearrangement. Heavy-chain-only antibodies (HCAb) are expressed at high levels, provided that the CH1 domain is deleted from the constant regions. HCAb...

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Identifiers

PMID: 17015837
DOI: 10.1073/pnas.0601108103

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