Article

Insufficiency of Genomic Structure in Immunoglobulin Locus for Inducing High-Frequency Gene Conversion in Variable Regions

2023-09-25

Abstract excerpt

Mammals, including humans and mice, employ V(D)J recombination and somatic hypermutation (SHM) to diversify their immunoglobulin (Ig) variable region repertoires, while domestic poultry, such as chickens and ducks, rely heavily on gene conversion (GCV) to achieve this diversification. Given the differences in the arrangement of Ig gene loci between chickens/ducks and humans/mice, we posited that the structural arr...

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Literature Corpus work: b9460c9b-0d2b-5619-b4c5-2f3f120559e1
DOI: 10.22541/au.169443764.40409226/v2

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