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Article

B-cell receptor physical properties affect relative IgG1 and IgE responses in mouse egg allergy

16 Sept 2022

Abstract excerpt

Mutated and unmutated IgE and IgG play different and partly opposing roles in allergy development, but the mechanisms controlling their relative production are incompletely understood. Here, we analyzed the IgE-response in murine food allergy. Deep sequencing of the complementary-determining region (CDR) repertoires indicated that an ongoing unmutated extrafollicular IgE response coexists with a germinal center...

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PMID: 36114245
DOI: 10.1038/s41385-022-00567-y

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