Article
DNA damage leads to progressive replicative decline but extends the life span of long-lived mutant animals.
Cell death and differentiation - 1 Dec 2013
Lans H, Lindvall J M, Thijssen K, Karambelas A E, Cupac D, Fensgård O, Jansen G, Hoeijmakers J H J, Nilsen H, Vermeulen W
Abstract excerpt
Human-nucleotide-excision repair (NER) deficiency leads to different developmental and segmental progeroid symptoms of which the pathogenesis is only partially understood. To understand the biological impact of accumulating spontaneous DNA damage, we studied the phenotypic consequences of DNA-repair deficiency in Caenorhabditis elegans. We find that DNA damage accumulation does not decrease the adult life span of...
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