Article
Persistent TFIIH binding to non-excised DNA damage causes cell and developmental failure.
Nature communications - 25 Apr 2024
Muniesa-Vargas Alba, Davó-Martínez Carlota, Ribeiro-Silva Cristina, van der Woude Melanie, Thijssen Karen L, Haspels Ben, Häckes David, Kaynak Ülkem U, Kanaar Roland, Marteijn Jurgen A, Theil Arjan F, Kuijten Maayke M P, Vermeulen Wim, Lans Hannes
Abstract excerpt
Congenital nucleotide excision repair (NER) deficiency gives rise to several cancer-prone and/or progeroid disorders. It is not understood how defects in the same DNA repair pathway cause different disease features and severity. Here, we show that the absence of functional ERCC1-XPF or XPG endonucleases leads to stable and prolonged binding of the transcription/DNA repair factor TFIIH to DNA damage, which...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.