Article
A two-tiered compensatory response to loss of DNA repair modulates aging and stress response pathways.
Aging - 31 Mar 2010
Fensgård Øyvind, Kassahun Henok, Bombik Izabela, Rognes Torbjørn, Lindvall Jessica Margareta, Nilsen Hilde
Abstract excerpt
Activation of oxidative stress-responses and downregulation of insulin-like signaling (ILS) is seen in Nucleotide Excision Repair (NER) deficient segmental progeroid mice. Evidence suggests that this is a survival response to persistent transcription-blocking DNA damage, although the relevant lesions have not been identified. Here we show that loss of NTH-1, the only Base Excision Repair (BER) enzyme known to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.