Article
Rapid degeneration of rod photoreceptors expressing self-association-deficient arrestin-1 mutant.
Cellular signalling - 1 Dec 2013
Song Xiufeng, Seo Jungwon, Baameur Faiza, Vishnivetskiy Sergey A, Chen Qiuyan, Kook Seunghyi, Kim Miyeon, Brooks Evan K, Altenbach Christian, Hong Yuan, Hanson Susan M, Palazzo Maria C, Chen Jeannie, Hubbell Wayne L, Gurevich Eugenia V, Gurevich Vsevolod V
Abstract excerpt
Arrestin-1 binds light-activated phosphorhodopsin and ensures timely signal shutoff. We show that high transgenic expression of an arrestin-1 mutant with enhanced rhodopsin binding and impaired oligomerization causes apoptotic rod death in mice. Dark rearing does not prevent mutant-induced cell death, ruling out the role of arrestin complexes with light-activated rhodopsin. Similar expression of WT arrestin-1...
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