Article
Induction of the unfolded protein response by constitutive G-protein signaling in rod photoreceptor cells.
The Journal of biological chemistry - 17 Oct 2014
Wang Tian, Chen Jeannie
Abstract excerpt
Phototransduction is a G-protein signal transduction cascade that converts photon absorption to a change in current at the plasma membrane. Certain genetic mutations affecting the proteins in the phototransduction cascade cause blinding disorders in humans. Some of these mutations serve as a genetic source of "equivalent light" that activates the cascade, whereas other mutations lead to amplification of the light...
Topics
- Animals
- Arrestins
- Cell Death
- Cell Survival
- Cyclic Nucleotide-Gated Cation Channels
- Endoplasmic Reticulum Stress
- G-Protein-Coupled Receptor Kinase 1
- GTP-Binding Protein alpha Subunits
- GTP-Binding Proteins
- Light
- Light Signal Transduction
- Mice
- Mice, Inbred BALB C