Article

Synchronized photoactivation of T4K rhodopsin causes a chromophore-dependent retinal degeneration that is moderated by interaction with phototransduction cascade components

2024-02-28

Abstract excerpt

Multiple mutations in the Rhodopsin gene cause sector retinitis pigmentosa in humans and a corresponding light-exacerbated retinal degeneration (RD) in animal models. Previously we have shown that the rhodopsin mutation T4K requires photoactivation to exert its toxic effect. Here we further investigated the mechanisms involved in rod cell death caused by T4K rhodopsin in Xenopus laevis . In this model, RD was p...

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Literature Corpus work: c05c277e-94ed-57cb-bd6e-b1142db16933
DOI: 10.1101/2024.02.27.582380

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