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Article

Helq acts in parallel to Fancc to suppress replication-associated genome instability.

Nucleic acids research - 1 Dec 2013

Luebben Spencer W, Kawabata Tsuyoshi, Akre Monica K, Lee Wai Long, Johnson Charles S, O'Sullivan M Gerard, Shima Naoko

Abstract excerpt

HELQ is a superfamily 2 DNA helicase found in archaea and metazoans. It has been implicated in processing stalled replication forks and in repairing DNA double-strand breaks and inter-strand crosslinks. Though previous studies have suggested the possibility that HELQ is involved in the Fanconi anemia (FA) pathway, a dominant mechanism for inter-strand crosslink repair in vertebrates, this connection remains...

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Share to Fanconi Anemia Complementation Group A Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24005041
DOI: 10.1093/nar/gkt676
PMCID: PMC3905894

Genes

HELQ
FANCC
FANCD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Helq acts in parallel to Fancc to suppress replication-associated genome instability.PMID 24005041Read ↗

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Fanconi anemia: causes and consequences of genetic instability.Semantic proximity Read ↗

FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability.Semantic proximity Read ↗

Opposing Roles of FANCJ and HLTF Protect Forks and Restrain Replication during StressSemantic proximity Read ↗

Folate stress as a Contributing Factor to Fanconi AnemiaSemantic proximity Read ↗

MERIT40 cooperates with BRCA2 to resolve DNA interstrand cross-links.Semantic proximity Read ↗

FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response.Semantic proximity Read ↗

Evidence for complete epistasis of null mutations in murine Fanconi anemia genes Fanca and Fancg.Semantic proximity Read ↗

C. elegans FANCD2 responds to replication stress and functions in interstrand cross-link repair.Semantic proximity Read ↗

FANCJ suppresses microsatellite instability and lymphomagenesis independent of the Fanconi anemia pathway.Semantic proximity Read ↗

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