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Article

MERIT40 cooperates with BRCA2 to resolve DNA interstrand cross-links.

Genes & development - 15 Sept 2015

Jiang Qinqin, Paramasivam Manikandan, Aressy Bernadette, Wu Junmin, Bellani Marina, Tong Wei, Seidman Michael M, Greenberg Roger A

Abstract excerpt

MERIT40 is an essential component of the RAP80 ubiquitin recognition complex that targets BRCA1 to DNA damage sites. Although this complex is required for BRCA1 foci formation, its physiologic role in DNA repair has remained enigmatic, as has its relationship to canonical DNA repair mechanisms. Surprisingly, we found that Merit40(-/-) mice displayed marked hypersensitivity to DNA interstrand cross-links (ICLs)...

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Topics

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Share to Adaptor Proteins, Signal Transducing
Share to BRCA2 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomal Instability

Share to DNA Helicases

Share to Fanconi Anemia Complementation Group D2 Protein

Share to Histone Chaperones

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Source

Open in PubMed Open full text

Identifiers

PMID: 26338419
DOI: 10.1101/gad.264192.115
PMCID: PMC4579352

Genes

BRCA1
BRCA2
FANCD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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